A groundbreaking systematic review recently published in Molecular Psychiatry called The serotonin theory of depression: A systematic umbrella review of the evidence challenges the long-held serotonin theory of depression. The comprehensive analysis examined multiple domains of serotonin research, including serotonin levels, receptors, and the effect of antidepressants, revealing little to no consistent evidence supporting the idea that depression is caused by serotonin deficiency.
This pivotal study urges the mental health community to rethink the biochemical model of depression and highlights the need for more nuanced approaches to understanding and treating this complex condition. Dive into the full article to explore the detailed findings and their implications for future research and treatment strategies.
Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2022). The serotonin theory of depression: A systematic umbrella review of the evidence. *Molecular Psychiatry*. https://doi.org/10.1038/s41380-022-01661-0